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Administration
May be taken with or without food.
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Contraindications
Untreated cobalamin deficiency (including untreated pernicious anaemia or other causes e.g. lifelong vegetarians), malignant disease.
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Special Precautions
Patient with folate-dependent tumours, haemolytic anaemia, alcoholism. Women with pre-existing diabetes, obesity, family history of neural tube defects, or previous pregnancy affected by neural tube defect. Not appropriate for monotherapy in pernicious, aplastic, or normocytic anaemias when anaemia is present with vitamin B12 deficiency. Children. Pregnancy and lactation. Monitoring Parameters Establish cobalamin status in all megaloblastic states (not only in pregnancy).
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Adverse Reactions
Gastrointestinal disorders: Abdominal distension, flatulence, nausea, bitter or bad taste.
Immune system disorders: Rarely, allergic reactions (e.g. rash, pruritus, erythema, urticaria, dyspnoea, shock); allergic sensitisation.
Metabolism and nutrition disorders: Rarely, anorexia.
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Drug Interactions
May reduce the plasma concentrations of anticonvulsants (e.g. phenytoin, phenobarbital, carbamazepine, valproic acid). Enhances the efficacy of lithium. May decrease the therapeutic effect of methotrexate. Increased elimination with aspirin. Reduced absorption with sulfasalazine and triamterene. Chloramphenicol and sulfamethoxazole + trimethoprim may interfere with folate metabolism.
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ATC Classification
V04CX02 - folic acid
B03BB01 - folic acid ; Belongs to the class of folic acid and derivatives. Used in the treatment of anemia. |
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